| Autor: |
TAYLOR, KENNETH M, CASALS, JORGE G, MITTRA, SUSHEELA M, BRANNAN, JOHN J, MORTON, JAMES J |
| Zdroj: |
Cardiovascular Research; Apr1980, Vol. 14 Issue 4, p199-205, 7p |
| Abstrakt: |
Recent studies have suggested a possible causative relationship between elevated plasma levels of Angiotensin II (All) and the vasoconstriction associated with conventional cardiopulmonary bypass. The haemodynamic effects of SQ14225, a specific angiotensin converting enzyme inhibitor, have been studied in a group of five dogs submitted to a 60 min period of cardiopulmonary bypass (CPB). A 20 min infusion of SQ14225 in a dose of 2 μg·kg−1·h−1 was administered to each dog 2 h after the end of the period of CPB. Measurements of peripheral vascular resistance index (PVRI), cardiac index (CI) and plasma levels of Angiotensin II were obtained at the start and end of the infusion period. The results in the five blocked dogs were compared with a control series of ten unblocked dogs submitted to an identical cardiopulmonary bypass regime. In the blocked dogs, PVRI fell significantly during infusion of SQ14225 from 38.27 units to 21.70 units (P < 0.01). There was a simultaneous significant increase in cardiac index from 3.00 to 3.98 litre·m2·min−1 (P < 0.01). Plasma Angiotensin II levels fell in the blocked dogs from 57 to 11.5 pg·cm−3 during the infusion period (normal levels
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| Databáze: |
Complementary Index |
| Externí odkaz: |
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