| Autor: |
Galinier, M., Balanescu, S., Fourcade, J., Dorobantu, M., Albenque, J. P., Massabuau, P., Doazan, J. P., Fauvel, J. M., Bounhoure, J. P. |
| Zdroj: |
European Heart Journal; 1997, Vol. 18 Issue 9, p1484-1491, 8p |
| Abstrakt: |
Objective To evaluate the prognostic value of arrhythmogenic markers in hypertensive patients. Design Two hundred and fourteen hypertensive patients without symptomatic coronary disease, systolic dysfunction, electrolyte disturbances or anti-arrhythmic therapy were included. Recordings were made of 12-lead standard ECGs with calculations of QT interval dispersion, 24 h Holter ECGs (204 patients), echocardiography (187 patients) and signal-averaged ECGs (125 patients). Results Baseline data: echocardiographic left ventricular hypertrophy was found in 63 patients (33·7%), non-sustained ventricular tachycardia (Lown class IV b) in 33 patients (16·2%), ventricular late potentials in 27 patients (21·6%). Mortality: after a mean follow-up of 42·4±26·8 months, global mortality was 11·2% (24 patients), cardiac mortality 7·9% (17 patients), sudden death 4·2% (nine patients). Univariate analysis: predictors of global, cardiac and sudden death were age ≥65 years, ECG strain pattern, Lown class IV b and QT interval dispersion >80 ms (P≤0·01). Left ventricular mass index was closely related to cardiac mortality (P=0·002). Multivariate analysis: only Lown class IV b was an independent predictor of global (RR 2·6, 95% CI 1·2–6·0) and cardiac mortality (RR 3·5, 95% CI 1·2–9·7). Conclusion In hypertensive patients, non-sustained ventricular tachycardia has a prognostic value. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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