| Autor: |
Gerber, B.L, Ordoubadi, F.F, Wijns, W, Vanoverschelde, J.-L.J, Knuuti, M.J, Janier, M, Melon, P, Blanksma, P.K, Bol, A, Bax, J.J, Melin, J.A, Camici, P.G |
| Zdroj: |
European Heart Journal; 2001, Vol. 22 Issue 18, p1691-1701, 11p |
| Abstrakt: |
Aims To assess the accuracy of positron emission tomography to predict recovery of global cardiac function after revascularization in patients with coronary artery disease.Methods and Results One hundred and seventy-eight patients (157 male, 58±10 years) with coronary artery disease and left ventricular dysfunction (mean ejection fraction 39±14%) were enrolled in six European centres. They underwent a common protocol for the assessment of viability using18F-fluoro-2-deoxyglucose (FDG) positron emission tomography during a standardized euglycaemic hyperinsulinaemic glucose clamp before revascularization by either surgery (n=140) or angioplasty (n=38). Seven patients were excluded because of incomplete revascularization of a dysfunctional region. Based on the recovery of global ejection fraction 2–6 months after revascularization, patients were classified into two groups: 82 patients who had a >5% improvement in ejection fraction postoperatively, and 89 patients without postoperative ejection fraction improvement. Optimal cut-off points for postoperative improvement of global cardiac function were computed, using receiver operating curve analysis. The highest sensitivity (79%) and specificity (55%) for predicting postoperative ejection fraction improvement by positron emission tomography was found when three or more dysfunctional segments had a relative FDG uptake >45% of normal remote myocardium (overall accuracy 67%).Conclusions In a large cohort of coronary patients with impaired ejection fraction, FDG positron emission tomography demonstrated high sensitivity and moderate specificity to predict improvement of cardiac function after coronary revascularization. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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