| Autor: |
ROMERO, J. CARLOS, MAK, SAI WAH, HOOBLER, S. W. |
| Zdroj: |
Cardiovascular Research; Sep1974, Vol. 8 Issue 5, p681-687, 7p |
| Abstrakt: |
A peptide converting enzyme inhibitor given intravenously to rabbits was shown to abolish the pressor response to injections of rabbit renin and of angiotensin-I and to augment the depressor response of bradykinin.In rabbits with acute two-kidney Goldblatt hypertension (2-KGH [one renal artery clamped, the other intact]) a total dose of 36 mg/kg infused for one hour lowered the blood pressure but not to a normal level. One week after removal of the intact kidney (acute one-kidney Goldblatt hypertension [1-KGH]) infusions of the peptide were still antihypertensive. Thirty to 60 days after removal of the intact kidney (chronic 1-KGH) the decapeptide had no antihypertensive effects. It is suggested that in the first two models hypertension is dependent on the renin-angiotensin system (RAS), but not in the chronic 1-KGH animal. Since the response to the new agent is not species specific and is well tolerated, it may become a valuable tool in investigating the role of the RAS in various forms of clinical hypertension. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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