| Autor: |
Young-il Kim, Hirai, Shizuka, Goto, Tsuyoshi, Chie Ohyane, Takahashi, Haruya, Tsugane, Taneaki, Konishi, Chiaki, Fujii, Takashi, Inai, Shuji, Iijima, Yoko, Aoki, Koh, Shibata, Daisuke, Takahashi, Nobuyuki, Kawada, Teruo |
| Předmět: |
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| Zdroj: |
PLoS ONE; Feb2012, Vol. 7 Issue 2, p1-8, 8p |
| Abstrakt: |
Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferatoractivated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9,11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo- ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARa agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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