| Autor: |
Mikloska, Zorka, Kesson, Alison M., Penfold, Mark E. T., Cunningham, Anthony L., Mikloska, Z, Kesson, A M, Penfold, M E, Cunningham, A L |
| Zdroj: |
Journal of Infectious Diseases; 1996, Vol. 173 Issue 1, p7-17, 11p |
| Abstrakt: |
In early recurrent herpetic lesions, CD4 T lymphocytes are the predominant infiltrating cells, and keratinocytes expressing major histocompatibility complex (MHC) class II antigens, induced by interferon-γ (IFN-γ), are the major site of herpes simplex virus (HSV)replication. IFN-γ pretreatment of human keratinocytes in vitro reduced MHC class I antigen down-regulation by HSV-1 infection and induced expression of HLA-DR that was unaltered by subsequent HSV-1 infection. Incubation of these infected keratinocytes with phosphonoacetic acid (PAA) almost completely inhibited expression of four major HSV glycoproteins, although expression of early proteins was not affected. Weak CD8 T lymphocyte cytotoxicity against IFN-γ-stimulated, HLA-DR-expressing HSV-1-infected keratinocytes was consistently directed to the immediate early/early proteins (all 9 patients tested) but against late proteins to a lesser degree (4/9 patients). However, CD4 T lymphocyte cytotoxicity was much greater and directed predominantly against late HSV-1 glycoproteins (all 9 subjects tested) in these cells. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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