| Autor: |
Testa, Douglas, Liao, Mei-June, Axelrod, Helena R., Kuchler, Martha, Yip, Yum-Keung, Kirkbright, Elisabeth |
| Zdroj: |
Journal of Infectious Diseases; 1992, Vol. 165 Issue 4, p757-760, 4p |
| Abstrakt: |
Human leukocyte-derived interferon-α (IFN-αn3) was used to treat condyloma acuminata patients in a double-blind placebo-eontrolled clinical study. The incidence of antibody formation to IFN-α was evaluated in matched patient sera from the control placebo and the IFN-an3 treatment groups. Sera from IFN-αn3-treated phase I cancer patients and untreated healthy donors were also evaluated. Three sensitive assay methods (ELISA, competitive immunoradiometric, and antiviral neutralization) were used in these evaluations. The overall levels of detectable binding anti-IFN-α antibodies in the patients were similar to those ofthe normal donors. No neutralizing antibodies were generated in the patients after repeated treatment with natural IFN-αn3. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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