| Autor: |
Jacobson, Mark A., Fusaro, Robert E., Galmarini, Mirta, Lang, William |
| Zdroj: |
Journal of Infectious Diseases; 1991, Vol. 164 Issue 5, p864-868, 5p |
| Abstrakt: |
Dehydroepiandrosterone (DHEA) and its interconvertible sulfate derivative (DHEA-S) are human androgenic steroids that have been reported to inhibit viral expression and have been associated with a decreased risk ofcancer. The relationship between serum DHEA and DHEA-S levels and subsequent progression to AIDS was investigated in a sample of human immunodeficiency virus (HIV)-infected men from the San Francisco Men's Health Study followed prospectively since 1984. Among 108 men seropositive for HIV at study entry and with CD4 lymphocyte counts of 200–499 µl 24 months later, serum DHEA levels below the lower limit of normal <180 ng/dl) at this later date were predictive ofsubsequent progression to AIDS (relative hazard = 2.34; 95% confidence interval = 1.18–4.63; P = .01) after controlling for hematocrit, age, and log absolute CD4 cell number in a Cox proportional hazards model. This is the first large prospective cohort in which an endocrinologic variable has been observed to independently predict progression to AIDS. These observations, in addition to recent in vitro data, suggest that DHEA might have a protective effect in HIV infection. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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