| Autor: |
Bodhidatta, Ladapom, Hoge, Charles W., Churnratanakul, Suraphol, Nirdnoy, Warawadee, Sampathanukul, Pichet, Tungtaem, Chatchai, Raktham, Suwanee, Smith, C. Dahlem, Echeverria, Peter |
| Zdroj: |
Journal of Infectious Diseases; 1993, Vol. 168 Issue 6, p1549-1553, 5p |
| Abstrakt: |
Serology to detect antibodies to Helicobacter pylori is not frequently used as a diagnostic tool in developing countries. When compared to a commercial ELISA, an ELISA constructed and validated in Thailand had a higher sensitivity (98% vs. 85%), specificity (76% vs. 66%), and negative predictive value (97% vs. 76%) for the detection of H. pylori infection among 104 patients with dyspepsia evaluated by endoscopy. The positive predictive value was 88% for both tests. Serum antibody levels fell significantly 5–8 months after eradication of infection in 8 Thai patients (P = .009). By 8 years of age, >50% of Thai persons living in urban and rural locations were seropositive. The low negative predictive value of the commercial ELISA limits the usefulness of this assay as a diagnostic tool in Thailand and suggests a need to reevaluate H. pylori serologic tests when used in populations living in developing countries. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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