| Autor: |
Kuppermann, Baruch D., Quiceno, Jose I., Aguilar, Marisa Flores, Connor, James D., Capparelli, Edmund V., Sherwood, Charles H., Freeman, William R. |
| Zdroj: |
Journal of Infectious Diseases; 1993, Vol. 168 Issue 6, p1506-1509, 4p |
| Abstrakt: |
To determine whether therapeutic intravitreal concentrations of ganciclovirare achieved after intravenous administration, vitreous samples were obtained intraoperatively from 23 eyes of 22 AIDS patients with retinal detachments associated with cytomegalovirus (CMV) retinitis. The mean intravitreal ganciclovir concentration of all samples was 0.93 ± 0.39 µg/mL (3.6 ± 1.5 µM). This level is near the published trough serum concentrations obtained with every-12-h intravenous dosing and well below the peak. It is significantlybelow the concentration of ganciclovir required to achieve 50% of viral plaque formation for many human CMV strains. Only a small decrease in vitreous drug levelswas observed as a function of time after last dose. Intravenous administration of ganciclovir results in near-steady-state subtherapeutic intravitreal ganciclovir concentrations for many CMV isolates. This may explain the difficultyof long-term complete suppression of CMV retinitis. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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