| Autor: |
Childs, James E., Ksiazek, Thomas G., Spiropoulou, Christina F., Krebs, John W., Morzunov, Sergey, Maupin, Gary O., Gage, Kenneth L., Rollin, Pierre E., Sarisky, John, Enscore, Russell E., Frey, Jennifer K., Peters, C. J., Nichol, Stuart T. |
| Zdroj: |
Journal of Infectious Diseases; 1994, Vol. 169 Issue 6, p1271-1280, 10p |
| Abstrakt: |
An outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was etiologically linked to a newly recognized hantavirus. Knowledge that hantaviruses are maintained in rodent reservoirs stimulated a field and laboratory investigation of 1696 small mammals of 31 species. The most commonly captured rodent, the deer mouse (Peromyscus maniculatus), had the highest antibody prevalence (30%) to four hantavirus antigens. Antibody also was detected in 10 other species of rodent and in 1 species of rabbit. Reverse transcriptase-polymerase chain reaction (RT-PCR) products of hantavirus from rodent tissues were indistinguishable from those from human HPS patients. More than 96% of the seropositive P. maniculatus were positive by RT-PCR, suggesting chronic infection. Antibody prevalences were similar among P. maniculatus trapped from Arizona (33%), New Mexico (29%), and Colorado (29%). The numeric dominance of P. maniculatus, the high prevalence of antibody, and the RT-PCR findings implicate this species as the primary rodent reservoir for a new hantavirus in the southwestern United States. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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