| Autor: |
Gunawan, Steven, Keck, Kristen, Laetsch, Alex, Hulme, Christopher |
| Zdroj: |
Molecular Diversity; Aug2012, Vol. 16 Issue 3, p601-606, 6p |
| Abstrakt: |
A concise two-step procedure for the synthesis of novel δ-lactam tetrazoles has been established via the Ugi-azide reaction using 5-oxohexanoic acid along with primary amines, isocyanides, and azidotrimethylsilane followed by 1,1′-carbonyldiimidazole-mediated intramolecular amide formation. Expansion to $${\varepsilon}$$-lactam tetrazole scaffolds was accomplished using methyl 6-oxoheptanoate via the same Ugi-azide reaction followed by basic hydrolysis and SOCl activation to enable lactam formation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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