| Autor: |
Harabuchi, Yasuaki, Faden, Howard, Yamanaka, Noboru, Duffy, Linda, Wolf, Judy, Krystofik, Deborah |
| Zdroj: |
Journal of Infectious Diseases; 1994, Vol. 170 Issue 4, p862-866, 5p |
| Abstrakt: |
The relationship between nasopharyngeal colonization with non typeable H. injluenzae and recurrent otitis media was assessed in 157 children followed prospectively from birth through 12 months of age. Forty-nine (31%) became colonized. Nasopharyngeal secretory IgA (sIgA) reactive with the P6 outer membrane protein was detected in all colonized children. Reduction or elimination of the organism was associated with a better mucosal immune response (560 ± 864 units/ng/ml, of sIgA) than was persistence in the nasopharynx (121 ± 81; P = .04). Forty colonized children (82%) and 61 noncolonized children (56%) developed otitis media (P = .004); colonized children were four times more likely to be classified as otitis prone (P = .003). The frequency of otitis media episodes was directly related to the frequency of colonization (r = .42, P < .01). These results demonstrate a strong relationship between nasopharyngeal colonization patterns and otitis media. The mucosal immune response may be important in elimination of potential pathogens from the respiratory tract. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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