| Autor: |
Periyasamy, Gomathi, Vaiyapuri, Thamil selvan, Kakoti, Bibhuti B., Gupta, Malaya, Mazumder, Upal Kanti |
| Předmět: |
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| Zdroj: |
Asian Journal of Pharmaceutical & Biological Research (AJPBR); 2011, Vol. 1 Issue 4, p447-453, 7p |
| Abstrakt: |
Objective :To investigate the possible analgesic and anti-inflammatory effect of methanol extract of the root of Artanema sesamoides Benth. Methods: Three models were used to study the extract effects on nociception, which were the acetic acid-induced writhing response, hot-plate method and the tail flick test in mice. The antiinflammatory effects were evaluated using carrageenan, dextran, histamine and serotonin induced rat paw oedema (acute) and cotton pellet induced granuloma (chronic) models in rats. Results :The study revealed that the extract exhibited significant (P < 0.001) analgesic effect at a dose of 50, 100 and 200 mg/kg body weight (b.w) per oral (p.o) in mice in all the models. In acute model, the MEAS also exhibited significant (P < 0.001) antiinflammatory effect in all the above mentioned doses. Maximum inhibition (59.95%) was noted at the dose of 200mg/kg b.w p.o after 3hr of drug treatment in histamine induced paw oedema, whereas the indomethacin (standard drug; 10mg/kg b.w p.o) produced 70.70% inhibition. In chronic model (cotton pellet induced granuloma) the MEAS 200 mg/kg b.w. p.o and indomethacin 10 mg/kg b.w. p.o showed that inhibition of granuloma formation 25.0% and 47.7% respectively (P < 0.001). The MEAS 200 mg/kg b.w. p.o and indomethacin 10 mg/kg b.w. p.o were effectively preventing the transudation of the fluid (from wet weight) 10.2% and 35.7% respectively. Conclusion :The present study revealed that the methanol extract of the root of Artanema sesamoides exhibited significant analgesic and antiinflammatory activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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