| Autor: |
Allaix, Marco, Degiuli, Maurizio, Giraudo, Giuseppe, Marano, Alessandra, Morino, Mario |
| Předmět: |
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| Zdroj: |
Surgical Endoscopy & Other Interventional Techniques; Sep2012, Vol. 26 Issue 9, p2609-2616, 8p, 4 Charts, 1 Graph |
| Abstrakt: |
Background: The purpose of this study was to evaluate short-term and oncologic outcomes of laparoscopic resection (LR) for patients with symptomatic stage IV colorectal cancer compared with open resection (OR). Methods: This study is a retrospective analysis of a prospective database. Patients with a minimum follow-up of 12 months after LR or OR for metastatic colorectal cancer were included. All analyses were performed on an 'intention-to-treat' basis. Results: A total of 162 consecutive patients submitted to LR and 127 submitted to OR were included. In the LR group, conversion rate was 26.5 %, mostly due to locally advanced disease (88.4 %). A greater risk of conversion was observed among patients with a tumor size greater than 5 cm regardless the tumor site ( P = 0.07). Early postoperative outcome was significantly better for LR group, with a shorter hospital stay ( P = 0.008), earlier onset of adjuvant treatment, and similar postoperative complications ( P = 0.853) and mortality rates ( P = 0.958). LR for rectal cancer was associated with a higher morbidity compared with colon cancer ( P = 0.058). During a median follow-up time of 72 months, there was no significant difference in overall survival between the two groups ( P = 0.622). Conclusions: LR for symptomatic metastatic CRC is safe and, compared with OR, is associated with a shorter hospital stay and with similar survival rates. Concerns remain about LR of bulky tumors and rectal cancers due to the increased risk of conversion and postoperative complications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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