Dynamics of Structural Transformations of BCG Granulomas and Expression of TNF-α and Granulocyte-Macrophage CSF by Macrophages In Vitro.

Autor:	Arkhipov, S., Shkurupy, V., Akhramenko, E., Iljine, D., Zaikovskaja, M.
Předmět:	GRANULOMA CELL culture CELL migration TUMOR necrosis factors MACROPHAGES CYTOPLASM THERAPEUTICS
Zdroj:	Bulletin of Experimental Biology & Medicine; Jul2012, Vol. 153 Issue 3, p343-347, 5p
Abstrakt:	The spleens were isolated from mice at different times after BCG infection and BCG granulomas were explanted and cultured in vitro. Cell migration, chemoattractant potential, and expression of TNF-α and granulocyte-macrophage CSF (GM-CSF) by macrophages migrated from granulomas were evaluated in granulomas. The number of macrophages able to migrate; migrating out of granulomas, expressing TNF-α and GM-CSF decreased with increasing the time after infection. The number of cells in 'dissociating' granulomas correlates with the number of macrophages containing live BCG mycobacteria in the cytoplasm. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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