Targeted Inactivation of the Gene Encoding Gamma-Synuclein Affects Anxiety Levels and Investigative Activity in Mice.

Autor: Kokhan, V., Bolkunov, A., Ustiugov, A., Van'kin, G., Shelkovnikova, T., Redkozubova, O., Strekalova, T., Buchman, V., Ninkina, N., Bachurin, S.
Předmět:
Zdroj: Neuroscience & Behavioral Physiology; Jul2012, Vol. 42 Issue 6, p575-581, 7p
Abstrakt: Gamma (γ) synuclein is a member of the family of synucleins, which are cytoplasmic, predominantly, neuronal, proteins found only in vertebrates. Significant quantities of γ-synuclein are found in the axons and presynaptic terminals of neurons located in brain areas responsible for forming emotions and memory. However, the involvement of γ-synucleins in controlling neuronal and synaptic processes underlying various types of behavior in humans and animals have not yet been studied. We provide the first demonstration that the absence of γ-synuclein increases orientational-investigative activity in a novel context and decreases the level of situational anxiety in animals. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index