Streptococcal Exanthem in a Blaschkolinear Pattern: Clinical Evidence for Genetic Mosaicism in Hypomelanosis of Ito.

Autor: Durán-McKinster, Carola, Moises, Celia, Rodríguez-Jurado, Rodolfo, Tamayo-Sánchez, Lourdes, Orozco-Covarrubias, Luz, Ruiz-Maldonado, Ramón
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Zdroj: Pediatric Dermatology; Sep/Oct2002, Vol. 19 Issue 5, p423, 3p, 2 Color Photographs
Abstrakt: Due to the presence of two different clones of cells in early embryogenesis, numerous congenital and acquired dermatoses have a linear distribution following the lines of Blaschko. Acquired inflammatory skin diseases are rarely observed in linear patterns. Our patient was born with macrocephaly, left eye glaucoma, and a left facial and contralateral corporal hemihypertrophy, cerebral dysgenesis, and skeletal abnormalities. Hypopigmented S-shaped linear macules on the trunk and linear streaks on the arms and legs were compatible with hypomelanosis of Ito. At 5 years of age the patient presented with an erythematous follicular exanthem compatible with scarlet fever exclusively in the lines of Blaschko. This fact suggests a genetic mosaicism. [ABSTRACT FROM AUTHOR]
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