Links Between Hypertension and Osteoporosis: Benidipine Ameliorates Osteoporosis in Ovariectomized Hypertensive Rats Through Promotion of Osteoblast Proliferation and Inhibition of Osteoclast Differentiation.

Autor: Shimizu, Hideo, Nakagami, Hironori, Yasumasa, Natsuki, Mariana, Osako, Kyutoku, Mariko, Koriyama, Hiroshi, Nakagami, Futoshi, Shimamura, Munehisa, Rakugi, Hiromi, Morishita, Ryuichi
Zdroj: Current Cardiovascular Risk Reports; Aug2012, Vol. 6 Issue 4, p274-280, 7p
Abstrakt: Recent studies have demonstrated that some antihypertensive drugs reduced the risk of bone fracture. Although calcium channel blockers (CCB) are used as first-line agents, there is no evidence that they prevent osteoporosis. In this study, we investigated the effects of 2 types of CCB, benidipine (L-/T-type CCB) and amlodipine (L-type CCB), on bone metabolism. In ovariectomized SHR, administration of benidipine resulted in a significant increase in the ratio of ALP to TRAP and a decrease in the number of osteoclasts in the tibia. Moreover, bone mineral density was significantly higher in the benidipine group compared with the amlodipine group, associated with a significant decrease in urinary deoxypyridinoline. In an in vitro study, benidipine promoted ALP expression and decreased receptor activator of NF-kB (RANK) ligand expression of human osteoblasts, indicating suppression of osteoclast differentiation. These pleiotropic effects of antihypertensive drugs such as benidipine might provide additional benefits in treating hypertensive postmenopausal women. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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