| Autor: |
Lecarpentier, Edouard, Dreux, Sophie, Blanc, Thomas, Schaub, Bruno, Ville, Yves, Mandelbrot, Laurent, Ghoneimi, Alaa El, Oury, Jean-François, Muller, Françoise |
| Zdroj: |
Prenatal Diagnosis; Jul2012, Vol. 32 Issue 7, p627-631, 5p |
| Abstrakt: |
ABSTRACT Objective The aim of the study was to evaluate a biochemical analysis of fluid sampled in utero from fetal abdominal cystic masses. Methods A retrospective study of 42 intra-abdominal cystic masses [ovarian cysts ( n = 22), cloaca ( n = 8), urodigestive fistulae ( n = 4), and urogenital sinuses ( n = 8)] was carried out. The control group ( n = 30) consisted of fetal urine. Seven biochemical markers were assayed: sodium, estradiol, β2-microglobulin, total proteins and digestive enzymes, gamma-glutamyl transpeptidase, aminopeptidase M, and intestinal alkaline phosphatase isoenzyme. Outcome of pregnancies and final diagnosis of intra-abdominal mass were known in all cases. Results Biochemical patterns allowed to demonstrate (1) an ovarian origin based on elevated level of estradiol and of total proteins (100% specificity, 100% sensitivity); (2) urodigestive fistula based on the presence of high levels of digestive enzymes (cloaca in female fetuses or recto-urethral fistula in male fetuses); and (3) a renal origin (urinary pattern with low total proteins and absence of digestive enzymes); however, a biochemical pattern could not differentiate between fetal urogenital sinus and megacystis. Conclusion Etiological diagnosis of a fetal cystic abdominal mass could impact both prenatal and postnatal management providing adapted prenatal counseling by a pediatric surgeon in surgically correctable congenital anomalies. © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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