Impaired quality of life after chikungunya virus infection: a 2-year follow-up study.
Autor: | Couturier, Elisabeth, Guillemin, Francis, Mura, Marie, Léon, Lucie, Virion, Jean-Marc, Letort, Marie-José, De Valk, Henriette, Simon, Fabrice, Vaillant, Véronique |
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Předmět: |
ACADEMIC medical centers
ANXIETY ARTHRITIS ARBOVIRUS diseases CHI-squared test CONFIDENCE intervals MENTAL depression HEALTH surveys LONGITUDINAL method MULTIVARIATE analysis QUALITY of life QUESTIONNAIRES REGRESSION analysis RESEARCH funding STATISTICS T-test (Statistics) COMORBIDITY DATA analysis SOCIAL support RELATIVE medical risk SEVERITY of illness index DISEASE duration DATA analysis software DESCRIPTIVE statistics SYMPTOMS DIAGNOSIS THERAPEUTICS |
Zdroj: | Rheumatology; Jul2012, Vol. 51 Issue 7, p1315-1322, 8p, 4 Charts, 1 Graph |
Abstrakt: | Objectives. To measure the frequency of and risk factors for rheumatic manifestations after chikungunya virus (CHIKV) infection and to assess their impact on quality of life (QoL).Methods. In a cohort study among 509 cases diagnosed in France, demographic and clinical characteristics were collected at baseline, and QoL status by 36-item short-form health survey (SF-36), a short form of the Arthritis Impact Measurement Scales 2 (AIMS2-SF) and General Health Questionnaire (GHQ-12) at follow-up. SF-36 scores were compared with population norms. Factors associated with QoL were identified in multivariate linear regression models.Results. A total of 391 (77%) patients participated (53.5% female, mean age 50.2 years). Median time from onset at follow-up was 23.4 months. Among 176 recovered patients, a shorter duration of symptoms was observed in younger age groups and male patients. The probability of full recovery at 1 year was 0.39. Those not recovered were older, had more comorbidities and a longer acute stage with joint swelling. Scores of physical and mental components of the SF-36 and GHQ-12 were low. The AIMS2-SF was affected mainly in symptoms, psychological and social dimensions. Recovered patients did not differ significantly from age- and gender-matched population SF-36 norms. Older age (P = 0.01–0.002) was associated with lower SF-36 scores. Other factors associated with lower SF-36, lower GHQ12 scores and higher AIMS2-SF dimensions were lack of recovery (P = 0.017 to <0.0001), presence of comorbidity (P = 0.005 to <0.0001) and a longer duration of acute stage (P = 0.047 to <0.0001).Conclusion. Medical follow-up with special attention to comorbidity providing information on possible chronic symptoms and giving support for potential depression and anxiety are recommended. [ABSTRACT FROM PUBLISHER] |
Databáze: | Complementary Index |
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