| Autor: |
Andrade, Vanessa L., Fernandes, Karla Simone, Bosco, Adriana Ap., Tanus-Santos, José Eduardo, Sandrim, Valeria Cristina |
| Předmět: |
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| Zdroj: |
DNA & Cell Biology; Jun2012, Vol. 31 Issue 6, p1054-1057, 4p |
| Abstrakt: |
The adipose tissue expansion is accompanied by remodeling of extracellular matrix performed by matrix metalloproteinases (MMPs). Higher plasma and tissue MMP-9 levels are found in obese; therefore, we evaluated if the functional C−1562T polymorphism (rs3918242) located in promoter region of the MMP-9 gene is associated with obesity in women. We studied 112 lean and 114 obese women. Plasma MMP-9 and tissue inhibitor of MMP-9 (TIMP)-1 were measured using enzyme-linked immunosorbent assay. We found different genotype frequencies between lean and obese women ( p=0.008), prevailing T-allele in obese (2.3-fold). However, although obese women present higher levels of plasma MMP-9, lack of modulation by the polymorphism was found (all p>0.05). Our findings suggest that C−1562T polymorphism may contribute to pathogenetic mechanisms involved in the development of obesity in women. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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