Bioavailability Assessment of Oral Coenzyme Q10 Formulations in Dogs.

Autor: Zaghloul, Abdel-azim, Gurley, Bill, Khan, Mansoor, Bhagavan, Hemmi, Chopra, Raj, Reddy, Indra
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Zdroj: Drug Development & Industrial Pharmacy; Nov2002, Vol. 28 Issue 10, p1195-1200, 6p, 1 Chart
Abstrakt: The purpose of this investigation was to compare the bioavailability of three coenzyme QIO (CoQlO) formulations in dogs using an open, randomized, multiple-dose crossover design. The formulations included a powder-filled capsule (A, control) and two soft gelatin formulations (Q-Gel[SUP®] as the water-miscible form of CoQlO, B and Q-Nol[SUPTM] as the water-miscible form of ubiquinol, the reduced form of CoQlO, C). Formulations were evaluated in pairs, allowing a washout period of 14 days prior to crossing over. Blood samples were collected from each animal prior to dosing to determine the endogenous plasma CoQ1O concentrations. Serial blood samples were collected for 72 hr and plasma CoQ1O concentrations were determined by high-performance liquid chromatography. Plasma concentration--time profiles were corrected for endogenous CoQ1O concentrations. Results showed that the relative bioavailabilities of formulations B and C were approximately 3.6 and 6.2-fold higher than that of control formulation A. The AUC(μg. hr/mL)±SD, C[SUBmax](μg/mL)±SD, and T[SUBmax] (hr)± SD for formulations A, B, and C were 1.6954±0.06, 6.0974±0.08, and 10.510±0.10; 0.096±0.035, 0.169±0.038, and 0.402±0.102; and 4.2±1.48, 4.1±1.57, and 4.5±0.58, respectively. While no significant differences were observed between T[SUBmax] values of the three formulations, the AUC and C[SUBmax] values for formulations B and C were significantly higher than those of the control ( p < 0.05). The present investigation demonstrates that soft gelatin capsules containing water-miscible CoO1O formulations B (Q-Gel[SUP®]) and C (Q-Nol[SUPTM]) are superior to powder-filled formulations with regard to their biopharmaceutical characteristics. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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