| Autor: |
Hilfiker-Kleiner, Denise, Haghikia, Arash, Hilfiker, Andres |
| Zdroj: |
Studies on Cardiovascular Disorders; 2010, p317-337, 21p |
| Abstrakt: |
Enhanced oxidative stress related to high metabolic turnover and elevated tissue oxygen requirements are the characteristic physiological state in pregnancy. In women with noneventful pregnancy and peripartum periods, this process appears to be paralleled by an increase in systemic antioxidant capacity. While these biochemical changes may not have pathophysiological consequences in healthy women, they may sensitize women with additional risk factors in late pregnancy and the early postpartum period to cardiovascular diseases such as preeclampsia and peripartum cardiomyopathy (PPCM). PPCM is a serious, potentially life-threatening heart disease of uncertain etiology in previously healthy women. Recent experimental findings associate unbalanced peripartum oxidative stress with the generation of a potent angiostatic, pro-apoptotic and proinflammatory factor, 16-kDa prolactin. Consistent with this notion, enhancing antioxidative capacity or pharmacological inhibition of prolactin secretion prevents PPCM in experimental models and seems to be promising in initial clinical approaches. Thus, unbalanced oxidative stress and high prolactin levels in combination seem to be key factors in PPCM and may therefore represent novel specific therapeutic targets to treat PPCM. The present article summarizes the current knowledge on peripartum oxidative stress mechanisms and associated cardiovascular disease forms and reports on potential pathomechanisms and novel treatment options for PPCM. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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