| Autor: |
Hastings, Ros, Howell, Rod |
| Zdroj: |
Quality Issues in Clinical Genetic Services; 2010, p305-314, 10p |
| Abstrakt: |
· Cytogenetics includes whole-genome analysis by means of chromosomal karyotyping and high resolution molecular techniques such as FISH, microarray, MLPA, QF-PCR, RT-PCR and RQ-PCR. The effective laboratory quality control system will determine the circumstances when it is appropriate to apply those different methodologies. · A systematic approach to the validation of the techniques will ensure that reliable, repeatable tests are undertaken. · Knowledge of the limitations of any results in relation to the technique and tissue being examined will minimise failure and misdiagnosis. · Accurate analysis and interpretation are critical quality parameters requiring extensive knowledge of the aetiology of cytogenetic abnormalities and risk factors. Training of staff in interpretation of the results and a comprehensive means of reporting normal and abnormal results underpins the service to the patient. · The cytogenetics laboratory providing a dependable and accurate diagnostic service will have in place a structured quality management system with reliable internal quality control and regular external audits such as EQA and accreditation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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