| Autor: |
Banton, Sophia, Roth, Zvi, Pavlovic, Mirjana |
| Zdroj: |
26th Southern Biomedical Engineering Conference SBEC 2010, April 30 - May 2, 2010, College Park, Maryland, Usa; 2010, p196-200, 5p |
| Abstrakt: |
The greatest roadblock in vaccine design is the lack of a complete understanding of how the immune system works. Greater understanding can be achieved via mathematical models that formalize biological ideas and their ability to extract non-intuitive information from biological experiments. Rational vaccine design (RVD) aims to maximize the production of pathogen-specific memory cells following vaccination. First, the Herz model for viral dynamics was simulated using MATLAB to analyze the naïve system΄s response to Ebola – a deadly hemorrhagic virus. The model was initialized for the unvaccinated system using biologically based data on Ebola virus cultivation in Vero cell-cultures. Simulations revealed generally non-quantified specifics of Ebola infection such as the virus΄ birth, natural death, and cellular infection rates. The second system, initialized with the rates above, modeled Ebola infection in a vaccinated individual using a modified Herz model with equations for memory T-cell formation and proliferation. T-cell populations were expanded under biologically mimicked rates and conditions. These results provide a quantified value for the number of memory T-cells necessary for vaccine efficacy in an individual; the specifications of what the vaccine must accomplish. Reversing the roles, these results may serve as RVD guidelines for biologically effective vaccines against the Ebola virus. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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