| Autor: |
Ward, A. D., Crukley, C., McKenzie, C., Montreuil, J., Gibson, E., Gomez, J. A., Moussa, M., Bauman, G., Fenster, A. |
| Zdroj: |
Prostate Cancer Imaging. Computer-aided Diagnosis, Prognosis & Intervention; 2010, p66-76, 11p |
| Abstrakt: |
Early and accurate diagnosis of prostate cancer enables minimally invasive therapies to cure the cancer with less morbidity. The purpose of this work is to non-rigidly register in vivo pre-prostatectomy prostate medical images to regionally-graded histopathology images from post-prostatectomy specimens, seeking a relationship between the multi parametric imaging and cancer distribution and aggressiveness. Our approach uses image-based registration in combination with a magnetically tracked probe to orient the physical slicing of the specimen to be parallel to the in vivo imaging planes, yielding a tractable 2D registration problem. We measured a target registration error of 0.85 mm, a mean slicing plane marking error of 0.7 mm, and a mean slicing error of 0.6 mm; these results compare favourably with our 2.2 mm diagnostic MR image thickness. Qualitative evaluation of in vivo imaging-histopathology fusion reveals excellent anatomic concordance between MR and digital histopathology. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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