| Autor: |
Hutzler, J. Matthew, Cook, Jack, Fleishaker, Joseph C. |
| Zdroj: |
Pharmacokinetics in Drug Development; 2011, p21-56, 36p |
| Abstrakt: |
Drug–drug interactions can represent a major public health issue. Drug metabolism science has evolved to the point where interactions with cytochrome P-450 isozymes can be predicted and potentially avoided or managed, but much work remains to allow accurate prediction of non-P-450 mediated interactions. Based on preclinical data, rational clinical plans can be developed to study potential drug–drug interactions in humans and develop labeling that allows optimal usage of new drugs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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