| Autor: |
Zhou, Guo Ling, Xin, Li, De Pei Liu |
| Zdroj: |
Biophysics of Dna-protein Interactions; 2011, p325-339, 15p |
| Abstrakt: |
Interactions between long-range genetic elements play key roles in regulating gene expression in a spatially and temporally restricted manner during differentiation and development in higher eukaryotic cells. With the aid of new technologies for analyzing chromatin structural organization, new long-range chromatin interactions have been discovered and interaction networks have been proposed. The underlying mechanisms by which these interactions influence gene expression have been explored at the level of three-dimensional chromatin structure. It has been possible to delineate the critical roles of two global regulator proteins, special AT-rich binding protein 1 and CTCF, in bridging long-range chromatin loops. This chapter discusses potential contributions of transcription factors, regulatory adaptor proteins, histone modifications, and noncoding RNAs in the formation of long-range chromatin interactions. The cellular consequences of chromatin topology regulation as well as methodologies used in the study of chromatin conformation are described. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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