| Autor: |
Haeberle, S., Hradetzky, D., Schumacher, A., Vosseler, M., Messner, S., Zengerle, R. |
| Zdroj: |
World Congress on Medical Physics & Biomedical Engineering, September 7 - 12, 2009, Munich, Germany (9783642038860); 2009, p359-362, 4p |
| Abstrakt: |
Drug delivery, i.e. the way a pharmacologically active substance is delivered to the body, has a significant impact on the therapeutic value of medication. The paper gives an overview on different drug delivery schemes and describes the limitations of the oral route, which is the current gold standard in the market. Following these limitations, plenty of alternative (parenteral) drug delivery technologies are currently under development. Many of them require the precise handling of small liquid volumes using small sized and low energy consuming devices. So microfluidics is a key enabling technology for these upcoming drug delivery devices. Ease of use and autonomous operation are the most important aspects for high acceptance and compliance of the patients. So for short term therapy (e.g. antibiotics), the devices should be small and portable. For long term therapy (e.g. cardiac), implantable devices are favorable since they can operate autonomously and deliver precise doses exactly to the target site (local therapy). The paper describes two examples for microfluidic drug delivery devices in more detail, namely the intra-oral transmucosal IntelliDrug system and the transdermal ChronopaDD device. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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