Nonself Detection in a Two-Component Cellular Frustrated System.

Autor: de Abreu, F. Vistulo, Mostardinha, P.
Zdroj: Artificial Immune Systems (9783642032455); 2009, p19-21, 3p
Abstrakt: The cellular frustration concept was first introduced in an ICARIS conference [1] as an alternative approach to accomplish specific and prompt intrusion detection in highly diverse systems. Cellular frustration uses two main assumptions: 1) that cells΄ activation are better modeled as cellular decisions and 2) that these cells΄ decisions require a finite amount of time to be triggered. These two assumptions have been gaining experimental support. It is now well established that T cells activation requires a considerable amount of time [2]. Experimental observations also suggest that interactions of T cells with APCs could be better modeled as cellular decisions rather than conventional probabilistic reactions [3],[4]. As a result from these assumptions the cellular frustration framework (CFF) is capable of reconciling two apparently opposing phenomena, namely high reactivity against nonself with total tolerance towards self [4]. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index