| Autor: |
Ajjan, Ramzi, Kearney, Mark T., Grant, Peter J. |
| Zdroj: |
Insulin Resistance; 2009, p179-205, 27p |
| Abstrakt: |
The prevalence of diabetes has considerably increased over the past few decades, and is predicted to reach 4.4% worldwide by 2030 (1). Hyperglycemia in diabetes is due to a combination of decreased tissue sensitivity to insulin, increased hepatic production of glucose, and impaired insulin secretion by the pancreas. Insulin resistance (IR) is a state that requires increased concentrations of insulin to achieve its desired biological effect and is tightly linked to excess white adipose tissue and obesity (2). In the early stages of IR, hyperinsulinemia takes place through additional insulin production by the pancreas, to compensate for ˵decreased insulin activity″, thereby keeping the blood glucose within the normal range. Without intervention to restore normal insulin sensitivity, the pancreas eventually loses its capacity to produce extra insulin (secondary β-cell failure) and the ensuing hyperglycemia results in the development of type 2 diabetes (T2DM). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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