| Autor: |
Shimizu, Yoshinaka, Okayama, Keisuke, Kano, Mitsuhiro, Kanetaka, Hiroyasu, Kikuchi, Masayoshi |
| Zdroj: |
Interface Oral Health Science 2007; 2007, p329-334, 6p |
| Abstrakt: |
This study examined the effects of graft material on osteoclast-mediated bone remodeling in guided bone regeneration (GBR). Sintered rabbit bone particles were used as the graft material. A polytetrafluoroethylene membrane was molded into a dome and anchored to the frontal bone in 16 male rabbits. The space under the membrane was filled with a blood clot (control group) or sintered bone particles (experimental group). Animals were killed 2, 4, 8, and 12 weeks after operation. The resected samples were fixed in 4% paraformaldehyde and demineralized. Paraffin-embedded histological sections were stained with hematoxylin and eosin and underwent a histochemical assay to determine tartrateresistant acid phosphate (TRAP) activity. The proportions of newly formed bone and graft particles and the numbers and densities of osteoclasts and multinucleated giant cells (MGCs) were calculated. The proportion of newly formed bone increased up to 4 weeks in both the control and experimental groups. Subsequently, the proportion decreased in the control group, but did not change significantly in the experimental group. Osteoclast density on newly formed bone was higher in the control group than that in the experimental group. We conclude that the use of a sintered bone graft inhibits bone resorption by osteoclasts. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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