| Autor: |
Tapia, JA, Macias-Garcia, B, Miro-Moran, A, Ortega-Ferrusola, C, Salido, GM, Peña, FJ, Aparicio, IM |
| Předmět: |
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| Zdroj: |
Reproduction in Domestic Animals; Jun2012, Vol. 47, p65-75, 0p, 1 Diagram |
| Abstrakt: |
Contents Sperm plasma membrane is a very important structure that functions to protect sperm against extracellular injuries and to respond to physiological challenges. It plays a crucial role during sperm capacitation, in sperm-egg interaction and, finally, in fertilization. Concerning sperm technology, possibly the most important factors causing damage in mammalian spermatozoa membranes are initiated by the osmotic stress generated by dehydration of the cells during freezing and thawing. These changes are rapidly derived to the plasma and organelle membranes that gradually experiment loss of membrane architecture, causing unbalanced production of reactive oxygen species and increased lipid peroxidation. Other procedures such as sperm sorting or liquid storage of sperm also induce harmful changes in the integrity of the membrane. The specific composition of lipids of the sperm membranes may provide clues for understanding the mechanisms behind the differences found in the response to stress in different species. In the present review, we deal with the composition, architecture and organization of the sperm plasma membrane, emphasizing the factors that can affect membrane integrity. The intracellular signalling pathways related with membrane reorganization during capacitation and acrosome reaction are also reviewed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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