| Autor: |
Bardossy, A. C., Petiti, H. G., Safar, N. L., Zlocowski, J. C., Zárate, A. H. |
| Předmět: |
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| Zdroj: |
Revista Experiencia Médica; 2011, Vol. 29 Issue 1, p5-15, 11p, 2 Charts, 1 Graph |
| Abstrakt: |
Neutropenia induced by chemotherapy is an immunological defect responsible for significant morbidity and mortality. We performed an observational prospective study in patients with febrile neutropenia secondary to chemotherapy during a 13-month period, in order to analyze the most prevalent pathogens and the response to empiric antibiotic therapy. We recorded 140 episodes of febrile neutropenia in 102 oncohaematologic patients. Microorganisms isolated from bacteremias were 23 (52,27%) gram-negative, 19 (43,18%) gram-positive and 2 (4,54%) anaerobes. Only 2 (4,54%) were polymicrobian. We found a high prevalence of MR coagulase-negative Staphyloccocci and gram-negative betalactamase producers of extended range. Mortality rate was 13.7%. Our study demonstrated that in patients with febril neutropenia the isolation of gram-negative bacteria continues to be higher than gram-positives, with elevated antibiotic resistance. In addition, we noted that patients with low risk according to the MASCC index and those who presented a monocyte count >100/ml at the beginning of the neutropenia episode, had lower incidence of bacteremia and better response to empiric antibiotic therapy with cefepime-amikacin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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