| Autor: |
Plakas, S. M., Said, K. R. El, Bencsath, F. A., Musser, S. M., Hayton, W. L. |
| Předmět: |
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| Zdroj: |
Xenobiotica; Jun98, Vol. 28 Issue 6, p605-616, 12p |
| Abstrakt: |
1. The disposition of proflavine (PRO) and acriflavine (ACR) were examined in channel catfish after intravascular (i.v.) dosing (1 mg kg) or waterborne exposure (10 mg l for 4 h). 2. After i.v. dosing, plasma concentration-time profiles of parent PRO and ACR were best described by two- and three-compartment pharmacokinetic models respectively. Terminal elimination half-lives of PRO and ACR in plasma were 8.7 and 11.4 h respectively. 3. In animals dosed with C-PRO or C-ACR, total drug equivalent concentrations were highest in the excretory organs and lowest in muscle, fat and plasma. In PRO-dosed animals, residues in the liver and trunk kidney were composed primarily of glucuronosyl and acetyl conjugates of PRO; residues in muscle were composed mostly ( 95%) of the parent drug. In ACR-dosed animals, the parent compound comprised 90% of the total residues in all tissues examined. 4. PRO and ACR were poorly absorbed in catfish during waterborne exposure. At the end of a 4-h exposure, parent PRO and ACR concentrations in muscle were 0.064 and 0.020 mug g respectively. Levels in muscle declined below the limit of determination (0.005 mug g) within 1-2 weeks. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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