| Autor: |
Xie, Jing-Xian, Lv, Guo-Rong, Chen, Qiu-Yue, Hou, Min |
| Zdroj: |
Prenatal Diagnosis; Jun2012, Vol. 32 Issue 6, p536-541, 6p |
| Abstrakt: |
ABSTRACT Objectives To evaluate the influence of congenital heart disease (CHD) or congestive heart failure (CHF) on fetal urine production rate (UPR) and to establish normal reference intervals. Methods A cross-sectional study was performed on normal fetuses ( n = 314) and on fetuses with CHD ( n = 49). CHD cases were divided into groups on the basis of heart function as defined by Huhta score: with CHF ( n = 11) and without CHF ( n = 38). Fetal bladder volume was measured by two-dimensional as well as three-dimensional ultrasound with the Virtual Organ Computer-aided Analysis technique. Results In normal fetuses, UPR increased with gestational age from a mean value of 4.5 mL/h at 21 weeks to 66.5 mL/h at 40 weeks. There were no significant differences in UPR between CHD cases without CHF and controls ( P = 0.581). However, fetuses with CHF had decreased UPR values (Controls vs. CHF, P = 0.007) compared with the controls. The interobserver and intraobserver variability for assessment of UPR was better using three-dimensional rather than two-dimensional US. Conclusions Fetal UPR can be reproducibly measured by the Virtual Organ Computer-aided Analysis technique. It appears that heart function, rather than CHD, affects fetal UPR. Fetal UPR may therefore be an additional indicator of CHF. © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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