| Autor: |
Ferrera, R., Hadour, G., Chiari, P., Montagna, P., Jegaden, O., Burhop, K., Lehot, J |
| Předmět: |
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| Zdroj: |
Transfusion Medicine; Oct2002, Vol. 12 Issue 5, p311-316, 6p |
| Abstrakt: |
Summary Diaspirin cross-linked haemoglobin (DCLHb™) is a haemoglobin-based oxygen carrier which had been proposed as a resuscitative solution to replace red cell transfusion in many clinical situations. The present study was designed to evaluate the effect of different volumes of DCLHb™ 10% (1, 5 and 10 mL kg-1 ) on the cardiovascular system during cardiopulmonary bypass (CPB), and to determine the effect of DCLHb™ (18 mL kg-1 ) when added directly to the CPB prime in anaesthetized swine. DCLHb™, when used as a priming solution, induced a significant increase (around 20%) in mean arterial pressure (MAP), which persisted during the entire period of CPB (P < 0·05) as compared with controls. Administration of increasing doses of DCLHb™ during the time course of CPB resulted in a progressive increase in MAP (P < 0·05), suggesting a linear dose–response relationship. Nicardipine, a calcium channel blocker, returned MAP to baseline. Finally, weaning of CPB was easier in animals that received DCLHb™, thereby suggesting a potential protective effect of free haemoglobin in this particular clinical situation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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