βhCG and PAPP-A in First Trimester: Predictive Factors for Preeclampsia?

Autor:	Mikat, Barbara, Zeller, Anna, Scherag, André, Drommelschmidt, Karla, Kimmig, Rainer, Schmidt, Markus
Předmět:	CHORIONIC gonadotropins FIRST trimester of pregnancy PLACENTAL hormones PREECLAMPSIA BLOOD proteins DURATION of pregnancy FETAL growth retardation HYPERTENSION in pregnancy
Zdroj:	Hypertension in Pregnancy; May2012, Vol. 31 Issue 2, p261-267, 7p
Abstrakt:	Objective. The aim of our study was to investigate a possible correlation between the expression of the placenta-secreted hormones, β-subunit of human chorionic gonadotrophin (βhCG) and pregnancy-associated plasma protein A (PAPP-A), during the first trimester screening and the development of preeclampsia. Methods. A total of 155 patients between 11 + 0 and 13 + 6 weeks of gestation were enrolled in this study. PAPP-A and βhCG levels were measured using the KRYPTOR® system. Results. The serum levels of βhCG were significantly higher in pregnancies which subsequently developed preeclampsia. The PAPP-A concentration did not differ significantly in pregnancies complicated by preeclampsia than in uncomplicated pregnancies. Conclusion. These results might contribute to developing new tests in the prediction of preeclampsia. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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