Centroblastic Diffuse Large B Cell Lymphoma Displays Distinct Expression Pattern and Prognostic Role of Apoptosis Resistance Related Proteins.

Autor:	Soares Faccion, Roberta, Magalhães Rezende, Lidia Maria, de Oliveira Romano, Sérgio, de Sá Bigni, Ricardo, Quintella Mendes, Gelcio Luiz, Ciuvalschi Maia, Raquel
Předmět:	B cell lymphoma GENE expression APOPTOSIS LYMPHOMAS PROTEINS IMMUNOHISTOCHEMISTRY DISEASE progression PROGNOSIS
Zdroj:	Cancer Investigation; Jun2012, Vol. 30 Issue 5, p404-414, 11p
Abstrakt:	Centroblastic diffuse large B cell lymphoma (DLBCL) samples were analyzed by immunohistochemistry to evaluate the expression of p53, Bcl-2, Survivin, XIAP, and Ki-67. Survivin was the only protein which expression exhibited a trend for impact in progression-free ( p = .077) and overall survival ( p = .054). In the Mann-Whitney test, Survivin expression correlated with a negative overall survival ( p = .045). These results appeared to be intimately related to Survivin cytoplasmic localization. Moreover, the anti-apoptotic proteins Bcl-2 and Survivin were less frequent in centroblastic DLBCL. Our results indicate that centroblastic DLBCL may be a disease with characteristic biology and clinical course and, therefore, specific prognostic factors. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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