| Autor: |
Moscovitch, David H., Laszlo, Charles A. |
| Zdroj: |
Journal of the Acoustical Society of America; 1972, Vol. 52 Issue 1A, p144-144, 1p |
| Abstrakt: |
In previous studies, 'start-stop' perfusion of scala tympani by artificial solutions produced temporary augmentation of the CM recorded by differential electrodes. The significance of hydrodynamic changes in scala tympani and the differential action of the artificial and natural perilymph on the hair cells in this phenomenon was investigated by computer simulation. In particular, it was determined from fluid-dynamic and experimental considerations that the artificial perilymph perfusate could be spontaneously replaced by natural perilymph at a rate of 0.8 μliter/min. The effect of this replacement was simulated on a computer model of the mechanoacoustical and mechano-electrical transduction process of the guinea-pig ear [C. A. Laszlo, J. Acoust. Soc. Amer. 38, 93(A) (1971)]. After simulated injection of a solution whose action was to suppress the CM generated by individual hair cells, the modeled gross CM was temporarily augmented by 40% above the preperfusion control, comparable to that observed in our perfusion experiments. The results indicate that the experimentally observed CM augmentation may be due to partial suppression and spontaneous progressive recovery of the CM generators, resulting in the detection of an apparant rather than a real CM augmentation. [Work supported by the Medical Research Council of Canada.] [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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