Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence.

Autor:	Smelson, David A, Losonczy, Mikios F, Davis, Craig W, Kaune, Maureen, Williams, John, Ziedonis, Douglas, Losonczy, Miklos F
Předmět:	RISPERIDONE SCHIZOPHRENIA COCAINE SUBSTANCE abuse & psychology ANTIPSYCHOTIC agents CLINICAL trials COMPARATIVE studies DRUG withdrawal symptoms RESEARCH methodology MEDICAL cooperation MOTIVATION (Psychology) PSYCHOLOGY RESEARCH SUBSTANCE abuse treatment COMORBIDITY DISEASE relapse PILOT projects EVALUATION research THERAPEUTICS
Zdroj:	Canadian Journal of Psychiatry; Sep2002, Vol. 47 Issue 7, p671-675, 5p, 1 Chart
Abstrakt:	Objective: To examine the efficacy of atypical neuroleptics for decreasing craving and drug relapses during protracted withdrawal in individuals dually diagnosed with schizophrenia and cocaine dependence.Method: We conducted a 6-week, open-label pilot study comparing risperidone with typical neuroleptics in a sample of withdrawn cocaine-dependent schizophrenia patients.Results: Preliminary results suggest that individuals treated with risperidone had significantly less cue-elicited craving and substance abuse relapses at study completion. Further, they showed a trend toward a greater reduction in negative and global symptoms of schizophrenia.Conclusion: Atypical neuroleptics may help reduce craving and relapses in this population. Future research should include more rigorous double-blind placebo-controlled studies with this class of medications. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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