HBOC Attenuates Intense Exercise-Induced Cardiac Dysfunction.
| Autor: | Li, T., Zhu, D., Zhou, R., Wu, W., Li, Q., Liu, J. |
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| Předmět: |
DRUG therapy for heart diseases
HEMOGLOBINS REACTIVE oxygen species ANALYSIS of variance ANIMAL experimentation BIOLOGICAL models CORONARY circulation ENZYME-linked immunosorbent assay EXERCISE HEART beat RATS RESEARCH funding RUNNING STATISTICS SUPEROXIDE dismutase T-test (Statistics) DATA analysis OXIDATIVE stress TREADMILLS REPEATED measures design DATA analysis software DESCRIPTIVE statistics THERAPEUTICS |
| Zdroj: | International Journal of Sports Medicine; May2012, Vol. 33 Issue 5, p338-345, 8p, 1 Diagram, 6 Charts |
| Abstrakt: | The purpose of this study was to investigate whether hemoglobin-based oxygen carrier (HBOC) could protect the heart from intense exercise-induced myocardial dysfunction. Adult male Sprague-Dawley rats were subjected to 5-h intense prolonged running on treadmill with or without HBOC pre-treatment. Immediately after exercise, the heart rate (HR) and oxygen delivery capacity of the blood were measured. After 1 h of rest, echocardiography was performed to assess the post-exercise cardiac function. Then all the hearts were isolated and perfused using the Langendorff model for 1 h. Our results proved that pronged exercise caused significant LV dysfunction, while HBOC pre-treatment attenuated such a damage, as evidenced by the increased oxygen delivery, cardiac fractional shortening (FS), rate-pressure product (RPP), ± dp/dt and coronary flow rate (CF) and decreased myocardial necrosis. The releases of cardiac enzymes, including creatine kinase-MB (CK-MB) and cardiac troponin-I (cTnI) were markedly reduced. No significant difference of cardiac infarct size was observed among groups. In addition, HBOC significantly elevated superoxide dismutase (SOD) activity and decreased hydrogen peroxide (H |
| Databáze: | Complementary Index |
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