Evaluation of genotoxic and oxidative effects in workers exposed to jet propulsion fuel.

Autor: Erdem, Onur, Sayal, Ahmet, Eken, Ayşe, Akay, Cemal, Aydın, Ahmet
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Zdroj: International Archives of Occupational & Environmental Health; May2012, Vol. 85 Issue 4, p353-361, 9p, 3 Charts, 1 Graph
Abstrakt: Purpose: Jet fuel is a common occupational exposure risk among military and civilian populations. The purpose of this study was to evaluate genotoxic and oxidative effects in workers occupational exposure to jet propulsion fuel (JP-8). Methods: In this study, sister-chromatid exchange (SCE), high frequency of SCE cells (HFCs), and micronuclei (MN) were determined for 43 workers exposed to JP-8 and 38 control subjects. We measured the antioxidant enzyme activities including that of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT). The levels of thiobarbituric acid-reactive substances (TBARS) were also studied. Urinary 1- and 2-naphthol excretion was used as a biomarker of occupational exposure to JP-8. Results: The results obtained from cytogenetic analysis show a statistically significant increase in frequency of SCE in the exposed workers when compared to controls ( P < 0.05). Interestingly, the mean value of the frequency (%o) of MN and HFCs for workers and controls did not show any statistical differences ( P > 0.05). Oxidative stress parameters were not statistically different between exposed and control groups except for TBARS levels. Conclusion: Urinary 1-and 2-naphthol levels of exposed workers were found to be significantly higher than those of control subjects. Occupational exposure to JP-8 resulted in no significant genotoxic and oxidative effects, while smoking is the principal confounding factor for the some parameters. To understand the genotoxic and oxidative effects of JP-8 exposure, further studies should be planned to find out whether human populations may be at increased risk for cancer because of the exposures related to occupation and lifestyle. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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