A Temperature Study on Critical Micellization Concentration of the Novel Platelet-Activating Factor Receptor Antagonist E5880 in Water by Electric Conductivity Measurements.

Autor:	Asai, Yasuyuki, Nomura, Teruko, Murahashi, Naokazu, Iwamoto, Kiyoshi
Předmět:	CHEMICAL inhibitors PLATELET activating factor ELECTRIC conductivity
Zdroj:	Drug Development & Industrial Pharmacy; May2000, Vol. 26 Issue 5, p555-558, 4p, 1 Chart
Abstrakt:	To clarify the behavior of the novel platelet-activating factor (PAF) receptor antagonist E5880 in aqueous solution, electric conductivity was measured at different temperatures (every 5°C), ranging from 15°C to 50°C. Critical micellization concentration (CMC) of E5880 was dependent on the temperature; at 30°C, the CMC value was smallest (0.143 mM). Below that temperature, the enthalpy for formation of the micelle (Δ H0m) was positive, and the formation of micelles was endothermic; above that temperature, Δ H0m was negative, and the formation of micelles was exothermic. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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