In Vitro and In Vivo Antitumor Effects of the Essential Oil from the Leaves of Guatteria friesiana.
Autor: | Britto, Anny C. S., Oliveira, Allan C. de A., Henriques, Raissa M., Cardoso, Gabriella M. B., Bomfim, Diogo S., Carvalho, Adriana A., Moraes, Manoel O., Pessoa, Claudia, Pinheiro, Maria L. B., Costa, Emmanoel V., Bezerra, Daniel P. |
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Předmět: |
LEAVES
ANALYSIS of variance ANTINEOPLASTIC agents BIOPHYSICS BODY weight CELL culture CONFIDENCE intervals DRUG administration CLINICAL drug trials ESSENTIAL oils LEUCOCYTES RESEARCH methodology MICE MOLECULAR structure NUCLEAR magnetic resonance spectroscopy ORAL drug administration PERITONEUM REGRESSION analysis RESEARCH funding STATISTICS TOXICITY testing CYTOMETRY DATA analysis DATA analysis software DESCRIPTIVE statistics THERAPEUTICS |
Zdroj: | Planta Medica; Mar2012, Vol. 78 Issue 4, p409-414, 6p, 1 Diagram, 3 Charts, 1 Graph |
Abstrakt: | Guatteria friesiana (W.A. Rodrigues) Erkens & Maas (synonym Guatteriopsis friesiana W.A. Rodrigues), popularly known as "envireira", is amedicinal plant found in the Brazilian and Colombian Amazon basin that is used in traditional medicine for various purposes. Recent studies on this species have demonstrated antimicrobial activity. In this study, the antitumor activity of the essential oil from the leaves of G. friesiana (EOGF) and its main components (α-, β-, and γ-eudesmol) were determined using experimental models. In the in vitro study, EOGF and its components α-, β-, and γ-eudesmol displayed cytotoxicity against tumor cell lines, showing IC |
Databáze: | Complementary Index |
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