STEREOSELECTIVE AND STEREOSPECIFIC SYNTHESIS OF 2-ALKYLIDENE-3-METHYLENE SUCCINIC ACID DIMETHYL ESTERS.

Autor: Béji, F., Lebreton, J., Villiéras, J., Amri, H.
Předmět:
Zdroj: Synthetic Communications; 2002, Vol. 32 Issue 21, p3273-3278, 6p, 1 Chart
Abstrakt: 1-Alkyl-2,3-dimethoxycarbonyl-1,3-butadienes 4 were synthesized via two different routes. In the first route, the Wittig-Horner reaction of the readily available phosphonate 2 with various aldehydes yielded the corresponding 1,3-dienes 4 with a good E stereoselectivity. The second route, using α-(bromomethyl) fumarate 1 under basic conditions, provides stereospecifically pure (E)-1,3-dienes 4. Scheme 1. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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