Deletion of the tumor-suppressor gene NF1 occurs in 5% of myeloid malignancies and is accompanied by a mutation in the remaining allele in half of the cases.

Autor:	Haferlach, C, Grossmann, V, Kohlmann, A, Schindela, S, Kern, W, Schnittger, S, Haferlach, T
Předmět:	TUMOR suppressor genes NEUROFIBROMIN ACUTE myeloid leukemia COMPARATIVE genomic hybridization PROTEIN microarrays DELETION mutation
Zdroj:	Leukemia (08876924); Apr2012, Vol. 26 Issue 4, p834-839, 6p, 2 Charts, 2 Graphs
Abstrakt:	The article focuses on the study concerning the deletion of tumor-suppressor gene neurofibromin 1 (NF1) in myeloid malignancies by array comparative genomic hybridization (CGH). It mentions that NF1 gene expression in 272 acute myeloid leukemia (AML) cases was evaluated using microarrays to analyze the role of NF1 in adult AML. It shows that deletion of NF1 occur in 7.3% of de novo AML.
Databáze:	Complementary Index
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