| Autor: |
Avakian, Arpenik, Kalina, Robert E., Sage, Helene E., Rambhia, Avni H., Elliott, Katherine E., Chuang, Elaine L., Clark, John I., Hwang, Jenq-Neng, Parsons-Wingerter, Patricia |
| Předmět: |
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| Zdroj: |
Current Eye Research; Apr2002, Vol. 24 Issue 4, p274, 7p |
| Abstrakt: |
Purpose. Evaluation of normal and abnormal vascular pattern in the human retina using a novel method: quantitative region-based fractal analysis. Methods. Binary (black/white) vascular patterns of the human retina originating at the optic disc were obtained by semi-automatic computer processing of digital images from 60-degree fundus fluorescein angiography of 5 normal eyes and 5 eyes with non-proliferative diabetic retinopathy (NPDR). As determined by image resolution, vascular patterns included vessels with diameters ≥50 µm and excluded small vessels and capillaries. The density of linearized (i.e., skeletonized) vascular patterns in the macular region versus paramacular region (termed "region-based" linearized vascular pattern) was quantified with the fractal dimension (D[sub f]) and confirmed by grid intersection (ρ[sub v]). Results. By region-based quantification, D[sub f] and ρ[sub v] were significantly higher in the normal macular region than in the NPDR macular region (p = 0.008 and p = 0.019, respectively). However, differences in D[sub f] and ρ[sub v] between the normal and NPDR paramacular regions were not strongly signficant (p = 0.168 and p = 0.337, respectively). Conclusions. Results from the retrospective analytical study demonstrate the feasibility of using quantitative region-based fractal analysis of early-stage vascular disease in the human retina. The results are encouraging for a broader study of diverse patient populations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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