The Significance of a Positive Fetal Fibronectin in the Setting of a Normal Cervical Length in Twin Pregnancies.
| Autor: | Nathan Fox, Andrei Rebarber, Ashley Roman, Chad Klauser, Daniel Saltzman |
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| Předmět: |
RISK factors in premature labor
ANTHROPOMETRY CERVIX uteri CHI-squared test CONFIDENCE intervals EPIDEMIOLOGY FIBRONECTINS FISHER exact test PREGNANCY T-test (Statistics) TWINS U-statistics DATA analysis MULTIPLE regression analysis PREDICTIVE tests RETROSPECTIVE studies DATA analysis software DESCRIPTIVE statistics |
| Zdroj: | American Journal of Perinatology; 2012, Vol. 29 Issue 4, p267-272, 6p |
| Abstrakt: | To estimate the risk of preterm birth in asymptomatic women with twin pregnancies with a normal cervical length (CL) and a positive fetal fibronectin (fFN), we reviewed a retrospective cohort of twin pregnancies delivered in our practice from 2005 to 2010. Patients were screened from 22 to 32 weeks with CL and fFN at 2- to 4-week intervals. We examined 244 patients with twin pregnancies and a normal CL (>25 mm) between 22 and 32 weeks and compared outcomes based on the fFN result. Fourteen (5.7%) patients had a positive fFN and 230 (94.3%) patients had a negative fFN. Positive fFN was associated with an increased the risk of spontaneous preterm birth < 37 weeks (85.7% versus 38.3%, p = 0.001), < 35 weeks (50% versus 11.8%, p < 0.001), < 34 weeks (35.7% versus 6.9%, p < 0.001), and < 32 weeks (21.4% versus 2.2%, p < 0.001). On adjusted analysis, a positive fFN was independently associated with preterm birth < 32 weeks (odds ratio 6.8, 95% confidence interval 1.42, 32.2) and gestational age at delivery (p = 0.001). In the setting of a normal CL, a positive fFN is significantly associated with preterm birth in asymptomatic twin pregnancies. Contingency model screening of fFN in asymptomatic twin pregnancies solely based on CL evaluation may fail to identify a cohort of at-risk patients. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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